Pathology and sensitivity of current clinical criteria in corticobasal syndrome.
Identifieur interne : 000484 ( Main/Exploration ); précédent : 000483; suivant : 000485Pathology and sensitivity of current clinical criteria in corticobasal syndrome.
Auteurs : Haruka Ouchi [Japon] ; Yasuko Toyoshima ; Mari Tada ; Mutsuo Oyake ; Izumi Aida ; Itsuro Tomita ; Akira Satoh ; Mitsuhiro Tsujihata ; Hitoshi Takahashi ; Masatoyo Nishizawa ; Takayoshi ShimohataSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Brain Diseases.
- diagnosis : Brain Diseases.
- etiology : Alzheimer Disease, Supranuclear Palsy, Progressive, Tauopathies.
- pathology : Basal Ganglia, Cerebral Cortex.
- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
The aim of this study was to investigate corticobasal syndrome with respect to underlying pathologies, the ability of current clinical criteria to detect early stages of disease, and symptoms and signs predicting background pathologies. We retrospectively analyzed the clinicopathological findings from patients with corticobasal syndrome. We also analyzed whether those findings fulfilled the diagnostic criteria for corticobasal degeneration (CBD). Finally, we investigated characteristic clinical features that are specific to each background pathology. Of 10 consecutive autopsied patients who had corticobasal syndrome (mean age ± standard deviation, 67.9 ± 9.3 years; male:female ratio, 6:4), three had corticobasal degeneration pathology, three had progressive supranuclear palsy, three had Alzheimer's disease, and one had atypical four-repeat tauopathy. Nine patients fulfilled Mayo criteria, and all 10 patients fulfilled modified Cambridge criteria at the later stage, but only two patients fulfilled either clinical criteria within 2 years of disease onset. Five patients fulfilled the clinical criteria for possible CBD (p-CBD), and one patient fulfilled the clinical research criteria for probable sporadic CBD (cr-CBD) at the later stage. Only two patients fulfilled the criteria for either p-CBD or cr-CBD within 2 years of disease onset. Although we could not find any predictive characteristic clinical features that were specific to CBD pathology, only patients with progressive supranuclear palsy developed apraxia of eyelid opening and cerebellar ataxia. Myoclonus and memory impairment, especially if they appear at an early stage of the disease, may predict Alzheimer's disease pathology. Sensitivity of the available clinical criteria for corticobasal syndrome was poor within 2 years of disease onset.
DOI: 10.1002/mds.25746
PubMed: 24259271
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The aim of this study was to investigate corticobasal syndrome with respect to underlying pathologies, the ability of current clinical criteria to detect early stages of disease, and symptoms and signs predicting background pathologies. We retrospectively analyzed the clinicopathological findings from patients with corticobasal syndrome. We also analyzed whether those findings fulfilled the diagnostic criteria for corticobasal degeneration (CBD). Finally, we investigated characteristic clinical features that are specific to each background pathology. Of 10 consecutive autopsied patients who had corticobasal syndrome (mean age ± standard deviation, 67.9 ± 9.3 years; male:female ratio, 6:4), three had corticobasal degeneration pathology, three had progressive supranuclear palsy, three had Alzheimer's disease, and one had atypical four-repeat tauopathy. Nine patients fulfilled Mayo criteria, and all 10 patients fulfilled modified Cambridge criteria at the later stage, but only two patients fulfilled either clinical criteria within 2 years of disease onset. Five patients fulfilled the clinical criteria for possible CBD (p-CBD), and one patient fulfilled the clinical research criteria for probable sporadic CBD (cr-CBD) at the later stage. Only two patients fulfilled the criteria for either p-CBD or cr-CBD within 2 years of disease onset. Although we could not find any predictive characteristic clinical features that were specific to CBD pathology, only patients with progressive supranuclear palsy developed apraxia of eyelid opening and cerebellar ataxia. Myoclonus and memory impairment, especially if they appear at an early stage of the disease, may predict Alzheimer's disease pathology. Sensitivity of the available clinical criteria for corticobasal syndrome was poor within 2 years of disease onset.</div>
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<name sortKey="Oyake, Mutsuo" sort="Oyake, Mutsuo" uniqKey="Oyake M" first="Mutsuo" last="Oyake">Mutsuo Oyake</name>
<name sortKey="Satoh, Akira" sort="Satoh, Akira" uniqKey="Satoh A" first="Akira" last="Satoh">Akira Satoh</name>
<name sortKey="Shimohata, Takayoshi" sort="Shimohata, Takayoshi" uniqKey="Shimohata T" first="Takayoshi" last="Shimohata">Takayoshi Shimohata</name>
<name sortKey="Tada, Mari" sort="Tada, Mari" uniqKey="Tada M" first="Mari" last="Tada">Mari Tada</name>
<name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name>
<name sortKey="Tomita, Itsuro" sort="Tomita, Itsuro" uniqKey="Tomita I" first="Itsuro" last="Tomita">Itsuro Tomita</name>
<name sortKey="Toyoshima, Yasuko" sort="Toyoshima, Yasuko" uniqKey="Toyoshima Y" first="Yasuko" last="Toyoshima">Yasuko Toyoshima</name>
<name sortKey="Tsujihata, Mitsuhiro" sort="Tsujihata, Mitsuhiro" uniqKey="Tsujihata M" first="Mitsuhiro" last="Tsujihata">Mitsuhiro Tsujihata</name>
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<country name="Japon"><noRegion><name sortKey="Ouchi, Haruka" sort="Ouchi, Haruka" uniqKey="Ouchi H" first="Haruka" last="Ouchi">Haruka Ouchi</name>
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